ClusterMine360: A Database of Microbial PKS/NRPS Biosynthesis

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Cluster Details

Accession # Y16952.3
Cluster Bases
If cluster is a subsegment of the GenBank sequence.
Name of Compound Family Balhimycin
Related Compound Families
Pathway Type NRPS
PKS - Type III
Producing Organism Amycolatopsis balhimycina DSM 5908
Phylum Actinobacteria
Organism Lineage
Description Amycolatopsis balhimycina biosynthetic gene cluster for balhimycin, strain DSM 5908
Sequencing References
Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908. Antimicrob. Agents Chemother. 1999 Jul; 43(7): 1565-73. PMID: 10390204
Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules. Microbiology (Reading, Engl.) 2002 Apr; 148(Pt 4): 1105-18. PMID: 11932455
A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine. J. Biol. Chem. 2001 Oct; 276(42): 38370-7. PMID: 11495926
The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-The Order of the Cyclization Steps This work was supported by the Deutsche Forschungsgemeinschaft (SFB 323) and by a grant of the EU (MEGATOP, QLK3-1999-00650). R. D. S. gratefully acknowledges the support of a Feodor-Lynen Fellowship granted by the Alexander-von-Humboldt Stiftung. We thank Corina Bihlmaier and Volker Pfeifer for help with transformation and Southern hybridization, J. A. Moss (La Jolla (USA)) for critical comments on the manuscript and Prof. Dr. M. E. Maier and Prof. Dr. H.-P. Fiedler (Tübingen) for generous support. Angew. Chem. Int. Ed. Engl. 2001 Dec; 40(24): 4688-4691. PMID: 12404385
Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase. Chem. Biol. 2002 Feb; 9(2): 225-35. PMID: 11880037
Other References
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antiSMASH Status View
Status of Domain Sequence Extraction Completed
Contributor Kyle Conway
Boddy Lab

Last modified Saturday, 08 September 2012 22:51 by System Admin